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Journal: Frontiers in Pharmacology
Article Title: Apocynum venetum L. leaves extract inhibits ferroptosis and improves renal fibrosis in diabetic kidney disease by regulating the Nrf2/HO-1 pathway
doi: 10.3389/fphar.2026.1807373
Figure Lengend Snippet: The effect of AVLE on the kidneys of db/db mice (A) Experimental design (B) Changes in kidney volume across groups (C,D) Blood glucose levels and body weight were measured at different time points (E,F) Changes in kidney weight index across groups (G-I) Serum BUN, SCr, and Cys-C levels in each group (J) The expression of KIM-1 protein was detected by the IHC method. Scale bar = 200 μm (K) Semi-quantitative analysis of KIM-1 protein immunohistochemistry (L,M) KIM-1 protein expression in renal lysates, with β-actin as the internal control. Data are expressed as mean ± SEM (n = 6). Compared with the CON group: ## p < 0.01, ### p < 0.001; compared with the MOD group: * p < 0.05, ** p < 0.01, *** p < 0.001.
Article Snippet:
Techniques: Expressing, Immunohistochemistry, Control
Journal: Frontiers in Pharmacology
Article Title: Apocynum venetum L. leaves extract inhibits ferroptosis and improves renal fibrosis in diabetic kidney disease by regulating the Nrf2/HO-1 pathway
doi: 10.3389/fphar.2026.1807373
Figure Lengend Snippet: Effects of AVLE on HG-induced renal injury and fibrosis-related proteins in HK-2 cells. (A) ZnPP’s impact on the survival of HK-2 cells induced with high glucose. (B,C) Western blot study of each group’s expression levels of the proteins FN, E-cadherin, α-SMA, and KIM-1. All data are presented as mean ± SEM (n = 3). Compared with the NG group: # p < 0.05, ## p < 0.01, ### p < 0.001; compared with the HG group: * p < 0.05, ** p < 0.01, *** p < 0.001.
Article Snippet:
Techniques: Western Blot, Expressing